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| Unknown | 1992-06-06 | 284.8 KB |
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| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
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| Newton Package (archive/newtonPackage)
| ext
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| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
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hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000460| 41 73 04 00 00 00 00 00 | 24 55 6e 69 71 75 65 5f |As......|$Unique_|
|00000470| 49 44 7b 59 52 42 31 33 | 31 30 30 7d 0d 0a 24 54 |ID{YRB13|100}..$T|
|00000480| 69 74 6c 65 7b 57 61 72 | 6e 69 6e 67 20 53 79 6d |itle{War|ning Sym|
|00000490| 70 74 6f 6d 73 20 6f 66 | 20 48 79 70 6f 67 6c 79 |ptoms of| Hypogly|
|000004a0| 63 61 65 6d 69 61 20 44 | 75 72 69 6e 67 20 54 72 |caemia D|uring Tr|
|000004b0| 65 61 74 6d 65 6e 74 20 | 57 69 74 68 20 48 75 6d |eatment |With Hum|
|000004c0| 61 6e 20 61 6e 64 20 50 | 6f 72 63 69 6e 65 20 49 |an and P|orcine I|
|000004d0| 6e 73 75 6c 69 6e 20 69 | 6e 20 44 69 61 62 65 74 |nsulin i|n Diabet|
|000004e0| 65 73 20 4d 65 6c 6c 69 | 74 75 73 7d 0d 0a 24 41 |es Melli|tus}..$A|
|000004f0| 75 74 68 6f 72 7b 42 65 | 72 67 65 72 2c 20 57 0d |uthor{Be|rger, W.|
|00000500| 0a 4b 65 6c 6c 65 72 2c | 20 55 0d 0a 48 6f 6e 65 |.Keller,| U..Hone|
|00000510| 67 67 65 72 2c 20 42 0d | 0a 4a 61 65 67 67 69 2c |gger, B.|.Jaeggi,|
|00000520| 20 45 7d 0d 0a 24 41 66 | 66 69 6c 69 61 74 69 6f | E}..$Af|filiatio|
|00000530| 6e 7b 4b 61 6e 74 6f 6e | 73 73 70 69 74 61 6c 2c |n{Kanton|sspital,|
|00000540| 20 42 61 73 65 6c 2c 20 | 53 77 69 74 7a 65 72 6c | Basel, |Switzerl|
|00000550| 61 6e 64 7d 0d 0a 24 4a | 6f 75 72 6e 61 6c 7b 4c |and}..$J|ournal{L|
|00000560| 61 6e 63 65 74 7d 0d 0a | 24 56 6f 6c 75 6d 65 7b |ancet}..|$Volume{|
|00000570| 31 7d 0d 0a 24 50 61 67 | 65 7b 31 30 34 31 2d 31 |1}..$Pag|e{1041-1|
|00000580| 30 34 34 7d 0d 0a 24 44 | 61 74 65 7b 4d 61 79 20 |044}..$D|ate{May |
|00000590| 31 33 2c 20 31 39 38 39 | 7d 0d 0a 24 59 42 56 6f |13, 1989|}..$YBVo|
|000005a0| 6c 7b 31 39 39 30 20 59 | 65 61 72 20 42 6f 6f 6b |l{1990 Y|ear Book|
|000005b0| 20 6f 66 20 45 6e 64 6f | 63 72 69 6e 6f 6c 6f 67 | of Endo|crinolog|
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|000005d0| 32 34 7d 0d 0a 24 59 42 | 45 64 69 74 6f 72 7b 4a |24}..$YB|Editor{J|
|000005e0| 6f 68 6e 20 44 2e 20 42 | 61 67 64 61 64 65 2c 20 |ohn D. B|agdade, |
|000005f0| 4d 2e 44 2e 7d 0d 0a 24 | 54 61 62 6c 65 7b 7d 0d |M.D.}..$|Table{}.|
|00000600| 0a 24 43 6f 6d 6d 65 6e | 74 61 74 6f 72 7b 52 2e |.$Commen|tator{R.|
|00000610| 53 2e 20 53 68 65 72 77 | 69 6e 2c 20 4d 2e 44 2e |S. Sherw|in, M.D.|
|00000620| 7d 0d 0a 0d 0a 43 6f 70 | 79 72 69 67 68 74 20 28 |}....Cop|yright (|
|00000630| 63 29 20 59 65 61 72 62 | 6f 6f 6b 20 4d 65 64 69 |c) Yearb|ook Medi|
|00000640| 63 61 6c 20 50 75 62 6c | 69 73 68 65 72 73 2c 20 |cal Publ|ishers, |
|00000650| 49 6e 63 2e 2c 20 31 39 | 39 30 0d 0a 0d 0a 31 39 |Inc., 19|90....19|
|00000660| 39 30 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |90 Year |Book of |
|00000670| 45 6e 64 6f 63 72 69 6e | 6f 6c 6f 67 79 20 28 52 |Endocrin|ology (R|
|00000680| 29 0d 0a 0d 0a 43 68 61 | 70 74 65 72 20 31 30 2d |)....Cha|pter 10-|
|00000690| 2d 44 69 61 62 65 74 65 | 73 20 4d 65 6c 6c 69 74 |-Diabete|s Mellit|
|000006a0| 75 73 20 61 6e 64 20 43 | 61 72 62 6f 68 79 64 72 |us and C|arbohydr|
|000006b0| 61 74 65 20 4d 65 74 61 | 62 6f 6c 69 73 6d 0d 0a |ate Meta|bolism..|
|000006c0| 0d 0a 4f 74 68 65 72 20 | 43 6f 6d 70 6c 69 63 61 |..Other |Complica|
|000006d0| 74 69 6f 6e 73 0d 0a 0d | 0a 2d 2d 2d 2d 2d 2d 2d |tions...|.-------|
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|00000720| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 57 61 72 6e 69 6e 67 |-------.|.Warning|
|00000730| 20 53 79 6d 70 74 6f 6d | 73 20 6f 66 20 48 79 70 | Symptom|s of Hyp|
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|00000750| 67 20 54 72 65 61 74 6d | 65 6e 74 20 57 69 74 68 |g Treatm|ent With|
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|00000770| 6e 65 0d 0a 49 6e 73 75 | 6c 69 6e 20 69 6e 20 44 |ne..Insu|lin in D|
|00000780| 69 61 62 65 74 65 73 20 | 4d 65 6c 6c 69 74 75 73 |iabetes |Mellitus|
|00000790| 0d 0a 0d 0a 42 65 72 67 | 65 72 20 57 2c 20 4b 65 |....Berg|er W, Ke|
|000007a0| 6c 6c 65 72 20 55 2c 20 | 48 6f 6e 65 67 67 65 72 |ller U, |Honegger|
|000007b0| 20 42 2c 20 4a 61 65 67 | 67 69 20 45 0d 0a 28 4b | B, Jaeg|gi E..(K|
|000007c0| 61 6e 74 6f 6e 73 73 70 | 69 74 61 6c 2c 20 42 61 |antonssp|ital, Ba|
|000007d0| 73 65 6c 2c 20 53 77 69 | 74 7a 65 72 6c 61 6e 64 |sel, Swi|tzerland|
|000007e0| 29 0d 0a 4c 61 6e 63 65 | 74 20 31 3a 31 30 34 31 |)..Lance|t 1:1041|
|000007f0| 2d 31 30 34 34 2c 20 4d | 61 79 20 31 33 2c 20 31 |-1044, M|ay 13, 1|
|00000800| 39 38 39 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |989..---|--------|
|00000810| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000820| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000830| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000840| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000850| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|00000860| 0a 0d 0a 20 20 20 20 20 | 53 75 72 76 65 79 20 72 |... |Survey r|
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|00000890| 66 65 72 20 6f 66 20 70 | 61 74 69 65 6e 74 73 20 |fer of p|atients |
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|000008b0| 0a 68 75 6d 61 6e 20 69 | 6e 73 75 6c 69 6e 20 6d |.human i|nsulin m|
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|000008e0| 70 74 6f 6d 73 20 6f 66 | 20 68 79 70 6f 67 6c 79 |ptoms of| hypogly|
|000008f0| 63 65 6d 69 61 2e 0d 0a | 48 6f 77 65 76 65 72 2c |cemia...|However,|
|00000900| 20 74 68 65 73 65 20 66 | 69 6e 64 69 6e 67 73 20 | these f|indings |
|00000910| 64 69 64 20 6e 6f 74 20 | 69 6e 64 69 63 61 74 65 |did not |indicate|
|00000920| 20 77 68 65 74 68 65 72 | 20 74 68 65 20 63 68 61 | whether| the cha|
|00000930| 6e 67 65 20 69 6e 20 73 | 79 6d 70 74 6f 6d 73 20 |nge in s|ymptoms |
|00000940| 77 61 73 0d 0a 61 74 74 | 72 69 62 75 74 61 62 6c |was..att|ributabl|
|00000950| 65 20 74 6f 20 74 68 65 | 20 63 68 61 6e 67 65 20 |e to the| change |
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|00000980| 74 6f 20 74 68 65 20 74 | 79 70 65 20 6f 66 0d 0a |to the t|ype of..|
|00000990| 69 6e 73 75 6c 69 6e 20 | 67 69 76 65 6e 2e 20 20 |insulin |given. |
|000009a0| 41 20 72 61 6e 64 6f 6d | 69 7a 65 64 2c 20 64 6f |A random|ized, do|
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|000009f0| 6e 65 20 74 6f 20 65 73 | 74 61 62 6c 69 73 68 20 |ne to es|tablish |
|00000a00| 77 68 65 74 68 65 72 20 | 74 68 65 72 65 20 69 73 |whether |there is|
|00000a10| 20 61 0d 0a 68 75 6d 61 | 6e 2d 69 6e 73 75 6c 69 | a..huma|n-insuli|
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|00000a70| 69 61 62 65 74 65 73 20 | 6d 65 6c 6c 69 74 75 73 |iabetes |mellitus|
|00000a80| 20 28 49 44 44 4d 29 2e | 0d 0a 20 20 20 20 20 4f | (IDDM).|.. O|
|00000a90| 66 20 33 32 20 70 61 74 | 69 65 6e 74 73 20 77 69 |f 32 pat|ients wi|
|00000aa0| 74 68 20 6c 6f 6e 67 2d | 74 65 72 6d 20 49 44 44 |th long-|term IDD|
|00000ab0| 4d 2c 20 31 38 20 62 65 | 67 61 6e 20 74 68 65 20 |M, 18 be|gan the |
|00000ac0| 73 74 75 64 79 20 77 69 | 74 68 20 68 75 6d 61 6e |study wi|th human|
|00000ad0| 20 69 6e 73 75 6c 69 6e | 0d 0a 61 6e 64 20 31 34 | insulin|..and 14|
|00000ae0| 20 77 69 74 68 20 70 6f | 72 63 69 6e 65 20 69 6e | with po|rcine in|
|00000af0| 73 75 6c 69 6e 2e 20 20 | 54 68 65 20 32 20 69 6e |sulin. |The 2 in|
|00000b00| 73 75 6c 69 6e 20 70 65 | 72 69 6f 64 73 20 65 61 |sulin pe|riods ea|
|00000b10| 63 68 20 6c 61 73 74 65 | 64 20 66 6f 72 20 31 32 |ch laste|d for 12|
|00000b20| 20 77 65 65 6b 73 2e 0d | 0a 49 6e 73 75 6c 69 6e | weeks..|.Insulin|
|00000b30| 20 64 6f 73 65 73 20 77 | 65 72 65 20 63 6f 6d 70 | doses w|ere comp|
|00000b40| 61 72 61 62 6c 65 20 64 | 75 72 69 6e 67 20 74 68 |arable d|uring th|
|00000b50| 65 20 32 20 70 65 72 69 | 6f 64 73 2c 20 61 73 20 |e 2 peri|ods, as |
|00000b60| 77 65 72 65 20 62 6c 6f | 6f 64 20 67 6c 75 63 6f |were blo|od gluco|
|00000b70| 73 65 0d 0a 70 72 6f 66 | 69 6c 65 73 20 61 6e 64 |se..prof|iles and|
|00000b80| 20 48 62 41 31 63 76 61 | 6c 75 65 73 2e 20 20 49 | HbA1cva|lues. I|
|00000b90| 6e 20 61 6c 6c 2c 20 31 | 37 31 20 65 70 69 73 6f |n all, 1|71 episo|
|00000ba0| 64 65 73 20 6f 66 20 68 | 79 70 6f 67 6c 79 63 65 |des of h|ypoglyce|
|00000bb0| 6d 69 61 20 6f 63 63 75 | 72 72 65 64 20 77 68 65 |mia occu|rred whe|
|00000bc0| 6e 0d 0a 68 75 6d 61 6e | 20 69 6e 73 75 6c 69 6e |n..human| insulin|
|00000bd0| 20 77 61 73 20 67 69 76 | 65 6e 20 61 6e 64 20 31 | was giv|en and 1|
|00000be0| 35 30 20 65 70 69 73 6f | 64 65 73 20 77 68 65 6e |50 episo|des when|
|00000bf0| 20 70 6f 72 63 69 6e 65 | 20 69 6e 73 75 6c 69 6e | porcine| insulin|
|00000c00| 20 77 61 73 20 67 69 76 | 65 6e 2e 20 20 54 68 65 | was giv|en. The|
|00000c10| 0d 0a 69 6e 69 74 69 61 | 6c 20 77 61 72 6e 69 6e |..initia|l warnin|
|00000c20| 67 20 73 79 6d 70 74 6f | 6d 73 20 6f 66 20 68 75 |g sympto|ms of hu|
|00000c30| 6e 67 65 72 20 61 6e 64 | 20 73 77 65 61 74 69 6e |nger and| sweatin|
|00000c40| 67 20 77 69 74 68 6f 75 | 74 20 63 6f 6e 63 6f 6d |g withou|t concom|
|00000c50| 69 74 61 6e 74 0d 0a 6e | 65 75 72 6f 67 6c 79 63 |itant..n|euroglyc|
|00000c60| 6f 70 65 6e 69 63 20 73 | 79 6d 70 74 6f 6d 73 20 |openic s|ymptoms |
|00000c70| 77 65 72 65 20 73 69 67 | 6e 69 66 69 63 61 6e 74 |were sig|nificant|
|00000c80| 6c 79 20 6d 6f 72 65 20 | 66 72 65 71 75 65 6e 74 |ly more |frequent|
|00000c90| 20 64 75 72 69 6e 67 20 | 74 68 65 20 70 65 72 69 | during |the peri|
|00000ca0| 6f 64 20 6f 66 0d 0a 70 | 6f 72 63 69 6e 65 20 69 |od of..p|orcine i|
|00000cb0| 6e 73 75 6c 69 6e 20 61 | 64 6d 69 6e 69 73 74 72 |nsulin a|dministr|
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|00000cd0| 67 20 74 68 65 20 70 65 | 72 69 6f 64 20 6f 66 20 |g the pe|riod of |
|00000ce0| 68 75 6d 61 6e 20 69 6e | 73 75 6c 69 6e 0d 0a 61 |human in|sulin..a|
|00000cf0| 64 6d 69 6e 69 73 74 72 | 61 74 69 6f 6e 2e 20 20 |dministr|ation. |
|00000d00| 41 74 20 74 68 65 20 65 | 6e 64 20 6f 66 20 74 68 |At the e|nd of th|
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|00000d50| 6c 65 20 68 75 6d 61 6e | 20 69 6e 73 75 6c 69 6e |le human| insulin|
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|00002910| 4d 2c 20 42 61 72 72 65 | 74 74 20 42 4a 2c 20 50 |M, Barre|tt BJ, P|
|00002920| 61 75 6c 20 4d 44 2c 20 | 47 65 6e 67 65 20 4d 2c |aul MD, |Genge M,|
|00002930| 20 57 69 74 68 65 72 73 | 20 4a 2c 20 46 61 72 69 | Withers| J, Fari|
|00002940| 64 20 4e 2c 0d 0a 4d 63 | 4d 61 6e 61 6d 6f 6e 20 |d N,..Mc|Manamon |
|00002950| 50 4a 0d 0a 28 4d 65 6d | 6f 72 69 61 6c 20 55 6e |PJ..(Mem|orial Un|
|00002960| 69 76 2c 20 53 74 2e 20 | 4a 6f 68 6e 27 73 2c 20 |iv, St. |John's, |
|00002970| 4e 65 77 66 6f 75 6e 64 | 6c 61 6e 64 29 0d 0a 4e |Newfound|land)..N|
|00002980| 20 45 6e 67 6c 20 4a 20 | 4d 65 64 20 33 32 30 3a | Engl J |Med 320:|
|00002990| 31 34 33 2d 31 34 39 2c | 20 4a 61 6e 20 31 39 2c |143-149,| Jan 19,|
|000029a0| 20 31 39 38 39 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d | 1989..-|--------|
|000029b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029f0| 2d 2d 2d 2d 2d 0d 0a 0d | 0a 41 62 73 74 72 61 63 |-----...|.Abstrac|
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|00004380| 70 6f 6e 74 61 6e 65 6f | 75 73 20 61 62 6f 72 74 |pontaneo|us abort|
|00004390| 69 6f 6e 73 20 68 61 64 | 20 68 69 67 68 65 72 0d |ions had| higher.|
|000043a0| 0a 66 61 73 74 69 6e 67 | 20 61 6e 64 20 70 6f 73 |.fasting| and pos|
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